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| http://purl.uniprot.org/citations/27419060 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elegans and is ubiquitously expressed. The FGT-1-mediated glucose uptake was almost completely defective in insulin/IGF-like signaling (IIS) mutants daf-2 and age-1, and this defect mainly resulted from the down-regulated FGT-1 protein expression. However, glycosylation may also be involved because OGA-1, an O-GlcNAcase, was essential for the function of FGT-1. Thus, our study showed that C. elegans can be a new powerful model system to study insulin regulation of GLUT."xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.org/dc/terms/identifier | "doi:10.1002/2211-5463.12068"xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/author | "Kitaoka S."xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/author | "Morielli A.D."xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/author | "Zhao F.Q."xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/name | "FEBS Open Bio"xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/pages | "576-585"xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/title | "FGT-1-mediated glucose uptake is defective in insulin/IGF-like signaling mutants in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/27419060 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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