| http://purl.uniprot.org/citations/27428651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27428651 | http://www.w3.org/2000/01/rdf-schema#comment | "Social encounters are associated with varying degrees of emotional arousal and stress. The mechanisms underlying adequate socioemotional balance are unknown. The medial amygdala (MeA) is a brain region associated with social behavior in mice. Corticotropin-releasing factor receptor type-2 (CRF-R2) and its specific ligand urocortin-3 (Ucn3), known components of the behavioral stress response system, are highly expressed in the MeA. Here we show that mice deficient in CRF-R2 or Ucn3 exhibit abnormally low preference for novel conspecifics. MeA-specific knockdown of Crfr2 (Crhr2) in adulthood recapitulated this phenotype. In contrast, pharmacological activation of MeA CRF-R2 or optogenetic activation of MeA Ucn3 neurons increased preference for novel mice. Furthermore, chemogenetic inhibition of MeA Ucn3 neurons elicited pro-social behavior in freely behaving groups of mice without affecting their hierarchal structure. These findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.4346"xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Eder M."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Gil S."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Elliott E."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Yizhar O."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Deussing J.M."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Kuperman Y."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Shemesh Y."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Sztainberg Y."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Mahn M."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Dine J."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Haramati S."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Ben-Efraim Y.J."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Forkosh O."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Manashirov S."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Adler E.S."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Anpilov S."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Ezra G."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Schneidman E."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Shlapobersky T."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/author | "Tabouy L."xsd:string |
| http://purl.uniprot.org/citations/27428651 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |