| http://purl.uniprot.org/citations/27431999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27431999 | http://www.w3.org/2000/01/rdf-schema#comment | "Palmitic acid (PA), a type of saturated fatty acids, induces cardiovascular diseases by causing cardiomyocyte apoptosis with unclear mechanisms. Akt participates in PA-induced cardiomyocyte apoptosis. GSK-3β is a substrate of Akt, we investigated its role in PA-induced apoptosis. We reveal that PA inhibits GSK-3β phosphorylation accompanied by inactivation of Akt in H9c2 cardiomyocytes. We also reveal that inhibition the activity of GSK-3β by its inhibitor LiCl or knockdown by siRNA significantly attenuates PA-induced cardiomyocyte apoptosis, this suggesting that GSK-3β plays a pro-apoptotic role. To detect its downstream factors, we analyzed the roles of JNK, p38 MAPK and β-arrestin 2 (β-Arr2). Here, we report that GSK-3β regulate PA-induced cardiomyocyte apoptosis by affecting the distribution of β-Arr2. PA diminishes the protein level of β-Arr2 and changes its distribution from nucleus to cytoplasm. Either inhibition of β-Arr2 by its siRNA or overexpression of its protein level by transfection of β-Arr2 full-length plasmid promotes PA-induced cardiomyocyte apoptosis, which remind us to focus on the changes of its location. β-Arr2 siRNA decreased the background level of β-Arr2 in nucleus in normal H9c2 cells. Overexpression of β-Arr2 increased cytoplasm level of β-Arr2 as PA did. While LiCl, the inhibitor of GSK-3β decreased PA-induced apoptosis, accompany with increased nucleus level of β-Arr2. Then we concluded that GSK-3β is closely associated with cardiomyocyte apoptosis induced by PA, it performs its pro-apoptotic function by affecting the location of β-Arr2. LiCl inhibits PA-induced cardiomyocyte apoptosis, which might provide novel therapeutic for cardiovascular diseases induced by metabolic syndrome."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-016-1272-z"xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Yin D."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Yue H."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/author | "Chang F."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/pages | "1045-1055"xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/title | "GSK-3beta promotes PA-induced apoptosis through changing beta-arrestin 2 nucleus location in H9c2 cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/27431999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27431999 |
| http://purl.uniprot.org/citations/27431999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27431999 |
| http://purl.uniprot.org/uniprot/#_A6HG47-mappedCitation-27431999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27431999 |
| http://purl.uniprot.org/uniprot/#_P29067-mappedCitation-27431999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27431999 |
| http://purl.uniprot.org/uniprot/A6HG47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27431999 |
| http://purl.uniprot.org/uniprot/P29067 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27431999 |