| http://purl.uniprot.org/citations/27434674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27434674 | http://www.w3.org/2000/01/rdf-schema#comment | "Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amino-acid starvation, when cognate deacyl-tRNA binds to the ribosomal A (aminoacyl-tRNA) site. We report four cryo-EM structures of E. coli RelA bound to the 70S ribosome, in the absence and presence of deacyl-tRNA accommodating in the 30S A site. The boomerang-shaped RelA with a wingspan of more than 100 Å wraps around the A/R (30S A-site/RelA-bound) tRNA. The CCA end of the A/R tRNA pins the central TGS domain against the 30S subunit, presenting the (p)ppGpp-synthetase domain near the 30S spur. The ribosome and A/R tRNA are captured in three conformations, revealing hitherto elusive states of tRNA engagement with the ribosomal decoding center. Decoding-center rearrangements are coupled with the step-wise 30S-subunit 'closure', providing insights into the dynamics of high-fidelity tRNA decoding."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.17029"xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Brilot A.F."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Korostelev A.A."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Madireddy R."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Loveland A.B."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/author | "Bah E."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/pages | "e17029"xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/title | "Ribosome•RelA structures reveal the mechanism of stringent response activation."xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27434674 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27434674 |
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