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| http://purl.uniprot.org/citations/27437695 | http://www.w3.org/2000/01/rdf-schema#comment | "XRN2 is a 5'-3' exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of DNA double-strand breaks (DSBs). We show that XRN2 undergoes DNA damage-inducible nuclear re-localization, co-localizing with 53BP1 and R loops, in a transcription and R-loop-dependent process. XRN2 loss leads to increased R loops, genomic instability, replication stress, DSBs and hypersensitivity of cells to various DNA damaging agents. We demonstrate that the DSBs that arise with XRN2 loss occur at transcriptional pause sites. XRN2-deficient cells also exhibited an R-loop- and transcription-dependent delay in DSB repair after ionizing radiation, suggesting a novel role for XRN2 in R-loop resolution, suppression of replication stress, and maintenance of genomic stability. Our study highlights the importance of regulating transcription-related activities as a critical component in maintaining genetic stability."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006107"xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Richard P."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Manley J.L."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Dang T.T."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Boothman D.A."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Morales J.C."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Motea E.A."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/author | "Patidar P.L."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/pages | "e1006107"xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/title | "XRN2 Links Transcription Termination to DNA Damage and Replication Stress."xsd:string |
| http://purl.uniprot.org/citations/27437695 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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