| http://purl.uniprot.org/citations/27455952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27455952 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody genes because of its low fidelity. To identify a role for Pol ι, we analyzed mutations in two strains of mice with deficiencies in the enzyme: 129 mice with negligible expression of truncated Pol ι, and knock-in mice that express full-length Pol ι that is catalytically inactive. Both strains had normal frequencies and spectra of mutations in the variable region, indicating that loss of Pol ι did not change overall mutagenesis. We next examined if Pol ι affected tandem mutations generated by another error-prone polymerase, Pol ζ. The frequency of contiguous mutations was analyzed using a novel computational model to determine if they occur during a single DNA transaction or during two independent events. Analyses of 2,000 mutations from both strains indicated that Pol ι-compromised mice lost the tandem signature, whereas C57BL/6 mice accumulated significant amounts of double mutations. The results support a model where Pol ι occasionally accesses the replication fork to generate a first mutation, and Pol ζ extends the mismatch with a second mutation."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20151227"xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Woodgate R."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Frank E.G."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Donigan K.A."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Gearhart P.J."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Saribasak H."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Lange S.S."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "McLenigan M.P."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Maul R.W."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "MacCarthy T."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/author | "Huston D.E."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/pages | "1675-1683"xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/title | "DNA polymerase iota functions in the generation of tandem mutations during somatic hypermutation of antibody genes."xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/27455952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27455952 |
| http://purl.uniprot.org/citations/27455952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27455952 |
| http://purl.uniprot.org/uniprot/#_E0CZD6-mappedCitation-27455952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27455952 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Z5-mappedCitation-27455952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27455952 |
| http://purl.uniprot.org/uniprot/#_G8DM21-mappedCitation-27455952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27455952 |
| http://purl.uniprot.org/uniprot/#_G8DM24-mappedCitation-27455952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27455952 |