| http://purl.uniprot.org/citations/27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27457956 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-κB signaling cascade relays external signals essential for B-cell growth and survival. This cascade is frequently hijacked by cancers that arise from the malignant transformation of germinal center (GC) B cells, underscoring the importance of deciphering the function of NF-κB in these cells. The NF-κB signaling cascade is comprised of two branches, the canonical and alternative NF-κB pathways, mediated by distinct transcription factors. The expression and function of the transcription factors of the alternative pathway, RELB and NF-κB2, in late B-cell development is incompletely understood. Using conditional deletion of relb and nfkb2 in GC B cells, we here report that ablation of both RELB and NF-κB2, but not of the single transcription factors, resulted in the collapse of established GCs. RELB/NF-κB2 deficiency in GC B cells was associated with impaired cell-cycle entry and reduced expression of the cell-surface receptor inducible T-cell costimulator ligand that promotes optimal interactions between B and T cells. Analysis of human tonsillar tissue revealed that plasma cells and their precursors in the GC expressed high levels of NF-κB2 relative to surrounding lymphocytes. Accordingly, deletion of nfkb2 in murine GC B cells resulted in a dramatic reduction of antigen-specific antibody-secreting cells, whereas deletion of relb had no effect. These results demonstrate that the transcription factors of the alternative NF-κB pathway control distinct stages of late B-cell development, which may have implications for B-cell malignancies that aberrantly activate this pathway."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1602728113"xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Klein U."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "De Silva N.S."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Anderson M.M."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Bhagat G."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Heise N."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Silva K."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/author | "Carette A."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/pages | "9063-9068"xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/title | "Transcription factors of the alternative NF-kappaB pathway are required for germinal center B-cell development."xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27457956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27457956 |
| http://purl.uniprot.org/citations/27457956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR2-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P4-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
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| http://purl.uniprot.org/uniprot/#_A0A140LI46-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Y5-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-27457956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27457956 |