| http://purl.uniprot.org/citations/27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27458135 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if and how mitophagy proceeds within specific cellular subtypes in vivo remains unclear, largely because of a lack of tractable tools and models. To address this, we have developed "mito-QC," a transgenic mouse with a pH-sensitive fluorescent mitochondrial signal. This allows the assessment of mitophagy and mitochondrial architecture in vivo. Using confocal microscopy, we demonstrate that mito-QC is compatible with classical and contemporary techniques in histochemistry and allows unambiguous in vivo detection of mitophagy and mitochondrial morphology at single-cell resolution within multiple organ systems. Strikingly, our model uncovers highly enriched and differential zones of mitophagy in the developing heart and within specific cells of the adult kidney. mito-QC is an experimentally advantageous tool of broad relevance to cell biology researchers within both discovery-based and translational research communities."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201603039"xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Thomson C."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Ganley I.G."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Prescott A.R."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "McWilliams T.G."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Munson M.J."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Muqit M.M."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Tamjar J."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/author | "Allen G.F."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/pages | "333-345"xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/title | "mito-QC illuminates mitophagy and mitochondrial architecture in vivo."xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/27458135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27458135 |
| http://purl.uniprot.org/citations/27458135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDI9-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA4-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLG5-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLP7-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLX1-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-27458135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458135 |