| http://purl.uniprot.org/citations/27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27458801 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor kappa B (NF-κB)-mediated transcription is an important mediator for cellular responses to DNA damage. Genotoxic agents trigger a 'nuclear-to-cytoplasmic' NF-κB activation signaling pathway; however, the early nuclear signaling cascade linking DNA damage and NF-κB activation is poorly understood. Here we report that Src-associated-substrate-during-mitosis-of-68kDa/KH domain containing, RNA binding, signal transduction associated 1 (Sam68/KHDRBS1) is a key NF-κB regulator in genotoxic stress-initiated signaling pathway. Sam68 deficiency abolishes DNA damage-stimulated polymers of ADP-ribose (PAR) production and the PAR-dependent NF-κB transactivation of anti-apoptotic genes. Sam68 deleted cells are hypersensitive to genotoxicity caused by DNA damaging agents. Upregulated Sam68 coincides with elevated PAR production and NF-κB-mediated anti-apoptotic transcription in human and mouse colon cancer. Knockdown of Sam68 sensitizes human colon cancer cells to genotoxic stress-induced apoptosis and genetic deletion of Sam68 dampens colon tumor burden in mice. Together our data reveal a novel function of Sam68 in the genotoxic stress-initiated nuclear signaling, which is crucial for colon tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.15018"xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Hodgson A."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Fu K."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Sears C.L."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/author | "Wier E.M."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/pages | "e15018"xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/title | "Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27458801 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27458801 |
| http://purl.uniprot.org/citations/27458801 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27458801 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_B2R7B5-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_B4DDX2-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_B4E043-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-27458801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27458801 |