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http://purl.uniprot.org/citations/27459526http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27459526http://www.w3.org/2000/01/rdf-schema#comment"

Context

Recently a potential role of betatrophin was shown in the postprandial switch from lipid to glucose metabolism.

Objective

The objective of the study was to analyze whether obesity is associated with altered postprandial betatrophin response and whether this could be restored by weight loss. Design, Setting, Participants, and Intervention: Oral glucose load was performed in 12 lean individuals at baseline as well as in 20 obese subjects before and after a 12-week structured weight-loss program at an endocrinology research center. Euglycemic hyperinsulinemic clamps were performed in the obese cohort. The effect of insulin and different glucose concentrations on betatrophin expression were analyzed in 3T3-L1 adipocytes.

Main outcome measure

Circulating betatrophin levels during a glucose challenge were measured.

Results

The betatrophin level decreases after an oral glucose intake (P < .001). This correlates with the increase of glucose levels (r = -0.396; P < .05). Hyperinsulinemia results in an increase of betatrophin. In vitro experiments in 3T3-L1 adipocytes confirmed that insulin and low glucose concentration increases betatrophin expression, whereas a further elevation of glucose levels blunts this effect. Obese subjects are characterized by lower fasting betatrophin (600.6 ± 364.4 vs 759.5 ± 197.9 pg/mL; P < .05) and a more pronounced betatrophin suppression during the glucose challenge. The impaired betatrophin response in obese subjects is restored after weight loss and is comparable with lean individuals.

Conclusions

Obesity is associated with increased betatrophin suppression after an oral glucose load, which is driven by increased hyperglycemia. Given the metabolic properties of betatrophin, this may indicate that betatrophin is tightly linked to obesity-associated metabolic disturbances. In line with such an assumption, weight loss almost completely eliminated this phenomenon."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.org/dc/terms/identifier"doi:10.1210/jc.2016-1788"xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Mai K."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Maurer L."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Spranger J."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Krude H."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Brachs S."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Bobbert T."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Decker A.M."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Brachs M."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Ernert A."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Jumpertz von Schwartzenberg R."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/author"Leupelt V."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/pages"4014-4020"xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/title"Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans."xsd:string
http://purl.uniprot.org/citations/27459526http://purl.uniprot.org/core/volume"101"xsd:string
http://purl.uniprot.org/citations/27459526http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27459526
http://purl.uniprot.org/citations/27459526http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27459526
http://purl.uniprot.org/uniprot/#_A0A0A0R784-mappedCitation-27459526http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27459526
http://purl.uniprot.org/uniprot/#_A0A1P9FG12-mappedCitation-27459526http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27459526
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http://purl.uniprot.org/uniprot/#_A6XGL2-mappedCitation-27459526http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27459526
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