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| http://purl.uniprot.org/citations/27466338 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledDopamine is central to reinforcement processing and exerts this function in species ranging from humans to fruit flies. It can do so via two different types of receptors (i.e., D1 or D2) that mediate either augmentation or abatement of cellular cAMP levels. Whereas D1 receptors are known to contribute to Drosophila aversive odor learning per se, we here show that D2 receptors are specific for support of a consolidated form of odor memory known as anesthesia-resistant memory. By means of genetic mosaicism, we localize this function to Kenyon cells, the mushroom body intrinsic neurons, as well as GABAergic APL neurons and local interneurons of the antennal lobes, suggesting that consolidated anesthesia-resistant memory requires widespread dopaminergic modulation within the olfactory circuit. Additionally, dopaminergic neurons themselves require D2R, suggesting a critical role in dopamine release via its recognized autoreceptor function. Considering the dual role of dopamine in balancing memory acquisition (proactive function of dopamine) and its "forgetting" (retroactive function of dopamine), our analysis suggests D2R as central player of either process.Significance statementDopamine provides different information; while it mediates reinforcement during the learning act (proactive function), it balances memory performance between two antithetic processes thereafter (retroactive function) (i.e., forgetting and augmentation). Such bidirectional design can also be found at level of dopamine receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels. Here, we report that consolidated anesthesia-resistant memory (ARM), but not other concomitant memory phases, are sensitive to bidirectional dopaminergic signals. By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM."xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4475-15.2016"xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/author | "Schwarzel M."xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/author | "Scholz-Kornehl S."xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/pages | "7936-7945"xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/title | "Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory."xsd:string |
| http://purl.uniprot.org/citations/27466338 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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