| http://purl.uniprot.org/citations/27469204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27469204 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon (IFN) regulatory factor 7 (IRF7) plays a key role in the production of IFN-α in response to viral infection, and phosphorylation at IRF7 C-terminal serine sites is prelude to its function. However, phosphatases that negatively regulate IRF7 phosphorylation and activity have not been reported. In this study, we have identified a conserved protein phosphatase 1 (PP1)-binding motif in human and mouse IRF7 proteins, and shown that PP1 physically interacts with IRF7. Exogenous expression of PP1 subunits (PP1α, β, or γ) ablates IKKε-stimulated IRF7 phosphorylation and dramatically attenuates IRF7 transcriptional activity. Inhibition of PP1 activity significantly increases IRF7 phosphorylation and IRF7-mediated IFN-α production in response to Newcastle disease virus (NDV) infection or Toll-like receptor 7 (TLR7) challenge, leading to impaired viral replication. In addition, IFN treatment, TLR challenges and viral infection induce PP1 expression. Our findings disclose for the first time a pivotal role for PP1 in impeding IRF7-mediated IFN-α production in host immune responses."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201646491"xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Ning S."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Yao Z.Q."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Moorman J.P."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/author | "Hall K.H."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/pages | "2409-2419"xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/title | "Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity."xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/27469204 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27469204 |
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