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| http://purl.uniprot.org/citations/27475912 | http://www.w3.org/2000/01/rdf-schema#comment | "Rubimetide (Met-Arg-Trp), which had been isolated as an antihypertensive peptide from an enzymatic digest of spinach ribulose-bisphosphate carboxylase/oxygenase (Rubisco), showed anxiolytic-like activity prostaglandin (PG) D2-dependent manner in the elevated plus-maze test after administration at a dose of 0.1mg/kg (ip.) or 1mg/kg (p.o.) in male mice of ddY strain. In this study, we found that rubimetide has weak affinities for the FPR1 and FPR2, subtypes of formyl peptide receptor (FPR). The anxiolytic-like activity of rubimetide (0.1mg/kg, ip.) was blocked by WRW4, an antagonist of FPR2, but not by Boc-FLFLF, an antagonist of FPR1, suggesting that the anxiolytic-like activity was mediated by the FPR2. Humanin, an endogenous agonist peptide of the FPR2, exerted an anxiolytic-like activity after intracerebroventricular (icv) administration, which was also blocked by WRW4. MMK1, a synthetic agonist peptide of the FPR2, also exerted anxiolytic-like activity. Thus, FPR2 proved to mediate anxiolytic-like effect as the first example of central effect exerted by FPR agonists. As well as the anxiolytic-like activity of rubimetide, that of MMK1 was blocked by BW A868C, an antagonist of the DP1-receptor. Furthermore, anxiolytic-like activity of rubimetide was blocked by SCH58251 and bicuculline, antagonists for adenosine A2A and GABAA receptors, respectively. From these results, it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2016.07.001"xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/author | "Yoshikawa M."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/author | "Yoshikawa A."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/author | "Ohinata K."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/author | "Sonada S."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/pages | "16-20"xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/title | "Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors."xsd:string |
| http://purl.uniprot.org/citations/27475912 | http://purl.uniprot.org/core/volume | "83"xsd:string |
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