| http://purl.uniprot.org/citations/27479603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27479603 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone-marrow-derived skeletal stem/stromal cell (SSC) self-renewal and function are critical to skeletal development, homeostasis and repair. Nevertheless, the mechanisms controlling SSC behaviour, particularly bone formation, remain ill-defined. Using knockout mouse models that target the zinc-finger transcription factors Snail or Slug, or Snail and Slug combined, a regulatory axis has been uncovered wherein Snail and Slug cooperatively control SSC self-renewal, osteoblastogenesis and bone formation. Mechanistically, Snail/Slug regulate SSC function by forming complexes with the transcriptional co-activators YAP and TAZ in tandem with the inhibition of the Hippo-pathway-dependent regulation of YAP/TAZ signalling cascades. In turn, the Snail/Slug-YAP/TAZ axis activates a series of YAP/TAZ/TEAD and Runx2 downstream targets that control SSC homeostasis and osteogenesis. Together, these results demonstrate that SSCs mobilize Snail/Slug-YAP/TAZ complexes to control stem cell function."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3394"xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/author | "Li X.Y."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/author | "Weiss S.J."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/author | "Feinberg T."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/author | "Keller E.T."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/pages | "917-929"xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/title | "Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation."xsd:string |
| http://purl.uniprot.org/citations/27479603 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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