| http://purl.uniprot.org/citations/27480238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27480238 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4(-/-)) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4(-/-) mice (Salm3(-/-); Salm4(-/-)) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3-LAR adhesion."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12328"xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kim H.M."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Nam J."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Lee S.G."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Choi S.Y."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Ko J."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Bae Y.C."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Cho Y.S."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Kang M.G."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Um J.W."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Choi T.Y."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Ko J.S."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Mah W."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Roh J.D."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Choi S.Y.'"xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Lie E."xsd:string |
| http://purl.uniprot.org/citations/27480238 | http://purl.uniprot.org/core/author | "Noh R."xsd:string |