| http://purl.uniprot.org/citations/27481848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27481848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27481848 | http://www.w3.org/2000/01/rdf-schema#comment | "As pathogen-associated molecular pattern sensors, the TLRs can detect diverse ligands to elicit either proinflammatory or anti-inflammatory responses, but the mechanism that dictates such contrasting immune responses is not well understood. In this work, we demonstrate that proline-proline-glutamic acid (PPE)17 protein of Mycobacterium tuberculosis induces TLR1/2 heterodimerization to elicit proinflammatory-type response, whereas PPE18-induced homodimerization of TLR2 triggers anti-inflammatory type responses. Ligation of TLR1/2 caused an increased recruitment of IL-1R-associated kinase (IRAK)1, MyD88, and protein kinase C (PKC)ε to the downstream TLR-signaling complex that translocated PKCε into the nucleus in an IRAK1-dependent manner. PKCε-mediated phosphorylation allowed the nuclear IRAK3 to be exported to the cytoplasm, leading to increased activation of ERK1/2, stabilization of MAPK phosphatase 1 (MKP-1), and induction of TNF-α with concomitant downregulation of p38MAPK. Silencing of TLR1 inhibited PPE17-triggered cytoplasmic export of IRAK3 as well as TNF-α induction, suggesting an important role of TLR1/2 heterodimer in regulating proinflammatory responses via the IRAK3-signaling pathway. In contrast, PPE18-mediated homodimerization of TLR2 caused poorer cytoplasmic export of nuclear IRAK3 and MKP-1 stabilization, resulting in increased p38MAPK activation. Our study hints to a novel mechanism that implicates PKCε-IRAK3-MKP-1 signaling in the regulation of MAPK activity and inflammatory cascades downstream of TLR2 in tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501816"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501816"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Mukhopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Mukhopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Qureshi R."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Qureshi R."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Udgata A."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/author | "Udgata A."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/pages | "1776-1787"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/pages | "1776-1787"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/title | "Transduction of functionally contrasting signals by two Mycobacterial PPE proteins downstream of TLR2 receptors."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/title | "Transduction of functionally contrasting signals by two Mycobacterial PPE proteins downstream of TLR2 receptors."xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/27481848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27481848 |
| http://purl.uniprot.org/citations/27481848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27481848 |
| http://purl.uniprot.org/citations/27481848 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27481848 |
| http://purl.uniprot.org/citations/27481848 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27481848 |