| http://purl.uniprot.org/citations/27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27484313 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) recruit the CCR4-NOT complex, which contains two deadenylases, CCR4 and CAF1, to promote shortening of the poly(A) tail. Although both CCR4 and CAF1 generally have a strong preference for poly(A) RNA substrates, it has been reported from yeast to humans that they can also remove non-A residues in vitro to various degrees. However, it remains unknown how CCR4 and CAF1 remove non-A sequences. Herein we show that Drosophila miRNAs can promote the removal of 3'-terminal non-A residues in an exonucleolytic manner, but only if an upstream poly(A) sequence exists. This non-A removing reaction is directly catalyzed by both CCR4 and CAF1 and depends on the balance between the length of the internal poly(A) sequence and that of the downstream non-A sequence. These results suggest that the CCR4-NOT complex has an intrinsic activity to remove the 3'-terminal non-A modifications downstream from the poly(A) tail."xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.057679.116"xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/author | "Tomari Y."xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/author | "Fukaya T."xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/author | "Niinuma S."xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/pages | "1550-1559"xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/title | "CCR4 and CAF1 deadenylases have an intrinsic activity to remove the post-poly(A) sequence."xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/27484313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27484313 |
| http://purl.uniprot.org/citations/27484313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27484313 |
| http://purl.uniprot.org/uniprot/#_A0A6M3Q6V5-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_E1JHY7-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_E1JIL4-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_C0MJE4-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q24572-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q7K112-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q8IMX0-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q8IMX1-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q9VCB6-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q8MTZ5-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q8MR41-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |
| http://purl.uniprot.org/uniprot/#_Q8I0I5-mappedCitation-27484313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27484313 |