| http://purl.uniprot.org/citations/27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27489351 | http://www.w3.org/2000/01/rdf-schema#comment | "Pro-inflammatory signaling pathways, especially interleukin 6 (IL-6), and reactive oxygen species (ROS) promote carcinogenesis in the liver. In order to elucidate the underlying oncogenic mechanism, we activated the IL-6 signal transducer glycoprotein 130 (gp130) via stable expression of a constitutively active gp130 construct (L-gp130) in untransformed telomerase-immortalized human fetal hepatocytes (FH-hTERT). As known from hepatocellular adenomas, forced gp130 activation alone was not sufficient to induce malignant transformation. However, additional challenge of FH-hTERT L-gp130 clones with oxidative stress resulted in 2-to 3-fold higher ROS levels and up to 6-fold more DNA-double strand breaks (DSB). Despite increased DNA damage, ROS-challenged FH-hTERT L-gp130 clones displayed an enhanced proliferation and rapidly developed colony growth capabilities in soft agar. As driving gp130-mediated oncogenic mechanism, we detected a decreased expression of antioxidant genes, in particular glutathione peroxidase 3 and apolipoprotein E, and an absence of P21 upregulation following ROS-conferred induction of DSB. In summary, an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.10956"xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Parplys A.C."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Schmidt-Arras D."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Lohse A.W."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Heim D."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Borgmann K."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Wege H."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Gil-Ibanez I."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/author | "Herden J."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/pages | "55639-55648"xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/title | "Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response."xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27489351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27489351 |
| http://purl.uniprot.org/citations/27489351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27489351 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L2-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L5-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |
| http://purl.uniprot.org/uniprot/#_O15281-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |
| http://purl.uniprot.org/uniprot/#_P40189-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |
| http://purl.uniprot.org/uniprot/#_Q13514-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |
| http://purl.uniprot.org/uniprot/#_Q17RA0-mappedCitation-27489351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27489351 |