| http://purl.uniprot.org/citations/27489352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27489352 | http://www.w3.org/2000/01/rdf-schema#comment | "S18 family of mitochondrial ribosomal proteins (MRPS18, S18) consists of three members, S18-1 to -3. Earlier, we found that overexpression of S18-2 protein resulted in immortalization and eventual transformation of primary rat fibroblasts. The S18-1 and -3 have not exhibited such abilities. To understand the differences in protein properties, the evolutionary history of S18 family was analyzed. The S18-3, followed by S18-1 and S18-2 emerged as a result of ancient gene duplication in the root of eukaryotic species tree, followed by two metazoan-specific gene duplications. However, the most conserved metazoan S18 homolog is the S18-1; it shares the most sequence similarity with S18 proteins of bacteria and of other eukaryotic clades. Evolutionarily conserved residues of S18 proteins were analyzed in various cancers. S18-2 is mutated at a higher rate, compared with S18-1 and -3 proteins. Moreover, the evolutionarily conserved residue, Gly132 of S18-2, shows genetic polymorphism in colon adenocarcinomas that was confirmed by direct DNA sequencing.Concluding, S18 family represents the yet unexplored important mitochondrial ribosomal proteins."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.10957"xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/author | "Klein G."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/author | "Kashuba E."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/author | "Kashuba V."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/author | "Mushtaq M."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/author | "Ali R.H."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/pages | "55649-55662"xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/title | "S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma."xsd:string |
| http://purl.uniprot.org/citations/27489352 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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