| http://purl.uniprot.org/citations/27496389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27496389 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeting acquired drug resistance represents the major challenge in the treatment of EGFR-driven non-small-cell lung cancer (NSCLC). Herein, we describe the structure-based design, synthesis, and biological evaluation of a novel class of covalent EGFR inhibitors that exhibit excellent inhibition of EGFR-mutant drug-resistant cells. Protein X-ray crystallography combined with detailed kinetic studies led to a deeper understanding of the mode of inhibition of EGFR-T790M and provided insight into the key principles for effective inhibition of the recently discovered tertiary mutation at EGFR-C797S."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.org/dc/terms/identifier | "doi:10.1002/anie.201605011"xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Zahedi R.P."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Engel J."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Bauer S."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Becker C."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Rauh D."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Schultz-Fademrecht C."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Muhlenberg T."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Kollipara L."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Ketzer J."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Keul M."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/author | "Lategahn J."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/name | "Angew Chem Int Ed Engl"xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/pages | "10909-10912"xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/title | "Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR."xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/27496389 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27496389 |
| http://purl.uniprot.org/citations/27496389 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27496389 |
| http://purl.uniprot.org/uniprot/#_P00533-mappedCitation-27496389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27496389 |
| http://purl.uniprot.org/uniprot/P00533 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27496389 |