http://purl.uniprot.org/citations/27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27497284 | http://www.w3.org/2000/01/rdf-schema#comment | "Prenatally, the cytokine CXCL12 regulates cortical interneuron migration, whereas its postnatal functions are poorly understood. Here, we report that CXCL12 is expressed postnatally in layer V pyramidal neurons and localizes on their cell bodies in the medial prefrontal cortex (mPFC), while its receptors CXCR4/CXCR7 localize to the axon terminals of parvalbumin (PV) interneurons. Conditionally eliminating CXCL12 in neonatal layer V pyramidal neurons led to decreased axon targeting and reduced inhibitory perisomatic synapses from PV+ basket interneurons onto layer V pyramidal neurons. Consequently, the mPFC of Cxcl12 conditional mutants displayed attenuated inhibitory postsynaptic currents onto layer V pyramidal neurons. Thus, postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits mPFC activity."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhw230"xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/author | "Rubenstein J.L.R."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/author | "Sohal V.S."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/author | "Vogt D."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/author | "Wu P.R."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/author | "Cho K.K.A."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/pages | "4303-4313"xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/title | "The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex."xsd:string |
http://purl.uniprot.org/citations/27497284 | http://purl.uniprot.org/core/volume | "27"xsd:string |
http://purl.uniprot.org/citations/27497284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27497284 |
http://purl.uniprot.org/citations/27497284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27497284 |
http://purl.uniprot.org/uniprot/#_A0A0R4J0N8-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P56485-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P70658-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_A1E2I3-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_E9Q2D4-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P40224-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_H7BX38-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P32848-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P48320-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |
http://purl.uniprot.org/uniprot/#_P60041-mappedCitation-27497284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27497284 |