| http://purl.uniprot.org/citations/27499013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27499013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27499013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/27499013 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-binding cassette transporters mediate the transbilayer movement of a vast number of substrates in or out of cells in organisms ranging from bacteria to humans. Current alternating access models for ABC exporters including the multidrug and Lipid A transporter MsbA from Escherichia coli suggest a role for nucleotide as the fundamental source of free energy. These models involve cycling between conformations with inward- and outward-facing substrate-binding sites in response to engagement and hydrolysis of ATP at the nucleotide-binding domains. Here we report that MsbA also utilizes another major energy currency in the cell by coupling substrate transport to a transmembrane electrochemical proton gradient. The dependence of ATP-dependent transport on proton coupling, and the stimulation of MsbA-ATPase by the chemical proton gradient highlight the functional integration of both forms of metabolic energy. These findings introduce ion coupling as a new parameter in the mechanism of this homodimeric ABC transporter."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12387"xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12387"xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "van Veen H.W."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "van Veen H.W."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Howard J."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Howard J."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Deery M.J."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Deery M.J."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Velamakanni S."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Velamakanni S."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Wei S.L."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/author | "Wei S.L."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/pages | "12387"xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/pages | "12387"xsd:string |
| http://purl.uniprot.org/citations/27499013 | http://purl.uniprot.org/core/title | "ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled."xsd:string |