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http://purl.uniprot.org/citations/27505846http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27505846http://www.w3.org/2000/01/rdf-schema#comment"

Objective

This study investigated the association between HLA-DRB1 and -DQB1 alleles and DRB1-DQB1 haplotypes, and polycystic ovary syndrome (PCOS) in Bahraini women.

Design

Case-control, retrospective study.

Methods

Study subjects comprised 80 women with PCOS, and 169 age- and ethnically-matched control women. DRB1 and DQB1 genotyping was done by PCR-SSP.

Results

Of the 13 DRB1 alleles and 5 DQB1 alleles identified, DRB1*10 (14.3% vs. 4.4%) and DRB1*14 (8.7% vs. 1.1%), along with DQB1*05 (35.0% vs. 23.9%), were the most frequent alleles in cases, while DRB1*11 (15.3% vs. 6.8%) was the frequent allele found in controls. The association of PCOS with DRB1*10 (Pc<0.001), DRB1*14 (Pc<0.001), DQB1*05 (Pc=0.040), but not DRB1*11 (Pc=0.076) persisted after correcting for multiple comparisons. DRB1-DQB1 haplotype analysis identified nine common shared haplotypes in women with PCOS and control women, with a frequency exceeding 1%. Significantly higher frequency of DRB1*10-DQB1*05 (12.4% vs. 3.1%) and DRB1*14-DQB1*03 (5.6% vs. 1.0%), and reduced frequency of DRB1*11-DQB1*03 (4.1% vs. 14.1%) haplotypes were seen in women with PCOS vs. control women, thus assigning PCOS-susceptible and -protective nature to these haplotypes, respectively. This association persisted after controlling for multiple comparisons.

Conclusion

Our results confirm an association of HLA-DRB1 and -DQB1 alleles and haplotypes with PCOS susceptibility in Bahraini Arabs, further underscoring the immunological/inflammatory nature of this disorder."xsd:string
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http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/author"Almawi W.Y."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/author"Messadi A."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/author"Malalla Z.H."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/author"Al-Jalahma J.A."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/author"Al-Madhi S.A."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/name"J Reprod Immunol"xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/pages"76-80"xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/title"Distribution of HLA DRB1 and DQB1 alleles and DRB1-DQB1 haplotypes among Bahraini women with polycystic ovary syndrome."xsd:string
http://purl.uniprot.org/citations/27505846http://purl.uniprot.org/core/volume"117"xsd:string
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