| http://purl.uniprot.org/citations/27508507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27508507 | http://www.w3.org/2000/01/rdf-schema#comment | "Anillin is a scaffold protein that recruits several proteins involved in cleavage furrow formation during cytokinesis. The role of anilllin in symmetric cell divisions in somatic cells has been intensively studied, yet its involvement in cleavage furrow formation is still elusive. In this study, we investigated the role of anillin in mammalian oocyte maturation and cytokinesis. We found that anillin is localized around the nucleus during the oocyte germinal-vesicle stage, and spreads to the cytoplasm after germinal vesicle breakdown. Thereafter, anillin concentrates at the site of the cleavage furrow from anaphase I to metaphase II. Disruption of anillin activity by microinjecting oocytes with specific siRNAs resulted in a failure of polar body extrusion and asymmetric division, and caused abnormal chromosome segregation during anaphase I. Furthermore, pharmacological inhibition of myosin light chain using Y-27632 or ML-7 resulted in decreased anillin expression. Collectively, our data suggest that anillin is an essential intracellular component that maintains the integrity of asymmetric division in mouse oocytes. Mol. Reprod. Dev. 83: 792-801, 2016 © 2016 Wiley Periodicals, Inc."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.org/dc/terms/identifier | "doi:10.1002/mrd.22688"xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/author | "Lee S.R."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/author | "Kim N.H."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/author | "Jo Y.J."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/author | "Namgoong S."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/name | "Mol Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/pages | "792-801"xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/title | "Anillin controls cleavage furrow formation in the course of asymmetric division during mouse oocyte maturation."xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/27508507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27508507 |
| http://purl.uniprot.org/citations/27508507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27508507 |
| http://purl.uniprot.org/uniprot/#_Q05CD5-mappedCitation-27508507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27508507 |
| http://purl.uniprot.org/uniprot/#_Q8K298-mappedCitation-27508507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27508507 |
| http://purl.uniprot.org/uniprot/Q05CD5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27508507 |
| http://purl.uniprot.org/uniprot/Q8K298 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27508507 |