| http://purl.uniprot.org/citations/27512039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27512039 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the mechanisms of early cardiac fate determination may lead to better approaches in promoting heart regeneration. We used a mesoderm posterior 1 (Mesp1)-Cre/Rosa26-EYFP reporter system to identify microRNAs (miRNAs) enriched in early cardiac progenitor cells. Most of these miRNA genes bear MESP1-binding sites and active histone signatures. In a calcium transient-based screening assay, we identified miRNAs that may promote the cardiomyocyte program. An X-chromosome miRNA cluster, miR-322/-503, is the most enriched in the Mesp1 lineage and is the most potent in the screening assay. It is specifically expressed in the looping heart. Ectopic miR-322/-503 mimicking the endogenous temporal patterns specifically drives a cardiomyocyte program while inhibiting neural lineages, likely by targeting the RNA-binding protein CUG-binding protein Elav-like family member 1 (Celf1). Thus, early miRNAs in lineage-committed cells may play powerful roles in cell-fate determination by cross-suppressing other lineages. miRNAs identified in this study, especially miR-322/-503, are potent regulators of early cardiac fate."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1608256113"xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Cooney A.J."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Bao W."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Liang R."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Gunaratne P.H."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Schwartz R.J."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Chopra M."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Benham A."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Mercola M."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Soibam B."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/author | "Azares A."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/pages | "9551-9556"xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/title | "miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification."xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27512039 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27512039 |