| http://purl.uniprot.org/citations/27514743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27514743 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian chromosome ends are protected by a specialized nucleoprotein complex called telomeres. Both shelterin, a telomere-specific multi-protein complex, and higher order telomeric chromatin structures combine to stabilize the chromosome ends. Here, we showed that TRF2, a component of shelterin, binds to core histones to protect chromosome ends from inappropriate DNA damage response and loss of telomeric DNA. The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones. The conserved arginine residues in the GAR domain of TRF2 are required for this interaction. A TRF2 mutant with these arginine residues substituted by alanine lost the ability to protect telomeres and induced rapid telomere shortening caused by the cleavage of a loop structure of the telomeric chromatin. These findings showed a previously unnoticed interaction between the shelterin complex and nucleosomal histones to stabilize the chromosome ends."xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.719021"xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/author | "Izumi T."xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/author | "Shimizu S."xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/author | "Konishi A."xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/pages | "20798-20810"xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/title | "TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends."xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27514743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27514743 |
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