| http://purl.uniprot.org/citations/27521049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27521049 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian Host-Cell Factor 1 (HCF-1), a transcriptional co-regulator, plays important roles during the cell-division cycle in cell culture, embryogenesis as well as adult tissue. In mice, HCF-1 is encoded by the X-chromosome-linked Hcfc1 gene. Induced Hcfc1(cKO/+) heterozygosity with a conditional knockout (cKO) allele in the epiblast of female embryos leads to a mixture of HCF-1-positive and -deficient cells owing to random X-chromosome inactivation. These embryos survive owing to the replacement of all HCF-1-deficient cells by HCF-1-positive cells during E5.5 to E8.5 of development. In contrast, complete epiblast-specific loss of HCF-1 in male embryos, Hcfc1(epiKO/Y), leads to embryonic lethality. Here, we characterize this lethality. We show that male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation. Subsequently, gastrulation does not take place. We note that the pattern of Hcfc1(epiKO/Y) lethality displays many similarities to loss of β-catenin function. These results reveal essential new roles for HCF-1 in early embryonic cell proliferation and development."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2016.08.008"xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Herr W."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Sung T.L."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Minocha S."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Bessonnard S."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Constam D.B."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/author | "Moret C."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/pages | "75-88"xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/title | "Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification."xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://purl.uniprot.org/core/volume | "418"xsd:string |
| http://purl.uniprot.org/citations/27521049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27521049 |
| http://purl.uniprot.org/citations/27521049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27521049 |
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