| http://purl.uniprot.org/citations/27521268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27521268 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor-5 (IRF5), a transcription factor critical for the induction of innate immune responses, contributes to the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE) in humans and mice. Lyn, a Src family kinase, is also implicated in human SLE, and Lyn-deficient mice develop an SLE-like disease. Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 pathway, thereby suppressing the transcriptional activity of IRF5 in a manner independent of Lyn's kinase activity. Conversely, Lyn did not inhibit NF-κB signaling, another major branch downstream of MyD88. Monoallelic deletion of Irf5 alleviated the hyperproduction of cytokines in TLR-stimulated Lyn(-/-) dendritic cells and the development of SLE-like symptoms in Lyn(-/-) mice. Our results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.07.015"xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Akiyama A."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Hirano H."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Miyashita S."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Suzuki S."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Umehara M."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Kimura A."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Yoshimatsu K."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Endo I."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Yanai H."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Nishiyama A."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Tsukahara K."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Kuromitsu J."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Ryo A."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Ban T."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Ichino M."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Sato G.R."xsd:string |
| http://purl.uniprot.org/citations/27521268 | http://purl.uniprot.org/core/author | "Takasuna M."xsd:string |