| http://purl.uniprot.org/citations/27523270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27523270 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FADD. Casp8(-/-)Mlkl(-/-) and Fadd(-/-)Mlkl(-/-) mice were viable and fertile but rapidly developed severe lymphadenopathy, systemic autoimmune disease, and thrombocytopenia. These morbidities occurred more rapidly and with increased severity in Casp8(-/-)Mlkl(-/-) and Fadd(-/-)Mlkl(-/-) mice compared to Casp8(-/-)Ripk3(-/-) or Fadd(-/-)Ripk3(-/-) mice, respectively. These results demonstrate that MLKL is an essential effector of aberrant necroptosis in embryos caused by loss of Caspase-8 or FADD. Furthermore, they suggest that RIPK3 and/or MLKL may exert functions independently of necroptosis. It appears that non-necroptotic functions of RIPK3 contribute to the lymphadenopathy, autoimmunity, and excess cytokine production that occur when FADD or Caspase-8-mediated apoptosis is abrogated."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.07.016"xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Lin A."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Alexander W.S."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "O'Reilly L.A."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Silke J."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Alvarez-Diaz S."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Dillon C.P."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Tanzer M.C."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Lalaoui N."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Rodriguez D.A."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Josefsson E.C."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Hakem R."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/author | "Lebois M."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/pages | "513-526"xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/title | "The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis."xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/27523270 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27523270 |
| http://purl.uniprot.org/citations/27523270 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27523270 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-27523270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523270 |