| http://purl.uniprot.org/citations/27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27523794 | http://www.w3.org/2000/01/rdf-schema#comment | "Together with its endogenous ligands (dynorphin), the kappa opioid receptor (KOR) plays an important role in modulating various physiological and pharmacological responses, with a classical G protein-coupled pathway mediating analgesia and non-G protein-dependent pathway, especially the β-arrestin-dependent pathway, eliciting side effects of dysphoria, aversion, drug-seeking in addicts, or even relapse to addiction. Although mounting evidence has verified a functional overlap between dynorphin/KOR and neurotensin/neurotensin receptor 1 (NTSR1) systems, little is known about direct interaction between the two receptors. Here, we showed that KOR and NTSR1 form a heterodimer that functions as a novel pharmacological entity, and this heterodimer, in turn, brings about a switch in KOR-mediated signal transduction, from G protein-dependent to β-arrestin-2-dependent. This was simultaneously verified by analyzing a KOR mutant (196th residue) that lost the ability to dimerize with NTSR1. We also found that dual occupancy of the heterodimer forced the β-arrestin-2-dependent pathway back into Gi protein-dependent signaling, according to KOR activation. These data provide new insights into the interaction between KOR and NTSR1, and the newly discovered role of NTSR1 acting as a switch between G protein- and β-arrestin-dependent pathways of KOR also suggests a new approach for utilizing pathologically elevated dynorphin/KOR system into full play for its analgesic effect with limited side effects."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2016.07.009"xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Ji B."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Xin Q."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/author | "Bai B."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/pages | "2719-2738"xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/title | "Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-biased pathway."xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
| http://purl.uniprot.org/citations/27523794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27523794 |
| http://purl.uniprot.org/citations/27523794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27523794 |
| http://purl.uniprot.org/uniprot/#_A0A5F9ZI09-mappedCitation-27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523794 |
| http://purl.uniprot.org/uniprot/#_A0A6H0WB68-mappedCitation-27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523794 |
| http://purl.uniprot.org/uniprot/#_A0A6H0WCN5-mappedCitation-27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523794 |
| http://purl.uniprot.org/uniprot/#_A6HG47-mappedCitation-27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523794 |
| http://purl.uniprot.org/uniprot/#_A8K4I6-mappedCitation-27523794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27523794 |