| http://purl.uniprot.org/citations/27529119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27529119 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection of professional antigen presenting cells by viruses can have a marked effect on these cells and important consequences for the generation of subsequent immune responses. In this study, we demonstrate that different strains of bovine viral diarrhea virus (BVDV) infect bovine dendritic cells differentiated from nonadherent peripheral monocytes (moDCs). BVDV did not cause apoptosis in these cells. Infection of moDC was prevented by incubating the virus with anti-E2 antibodies or by pretreating the cells with recombinant E2 protein before BVDV contact, suggesting that BVDV infects moDC through an E2-mediated mechanism. Virus entry was not reduced by incubating moDC with Mannan or ethylenediaminetetraacetic acid (EDTA) before infection, suggesting that Ca(2+) and mannose receptor-dependent pathways are not mediating BVDV entry to moDC. Infected moDC did not completely upregulate maturation surface markers. Infection, but not treatment with inactivated virus, prevented moDC to present a third-party antigen to primed CD4(+) T cells within the first 24 hours postinfection (hpi). Antigen-presenting capacity was recovered when viral replication diminished at 48 hpi, suggesting that active infection may interfere with moDC maturation. Altogether, our results suggest an important role of infected DCs in BVDV-induced immunopathogenesis."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.org/dc/terms/identifier | "doi:10.1089/vim.2016.0047"xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Cardoso N."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Malacari D.A."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Capozzo A.V."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Czepluch W."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Franco-Mahecha O.L."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Mansilla F.C."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Quintana M.E."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/author | "Trotta M.V."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/name | "Viral Immunol"xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/pages | "417-429"xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/title | "Bovine Viral Diarrhea Virus Infects Monocyte-Derived Bovine Dendritic Cells by an E2-Glycoprotein-Mediated Mechanism and Transiently Impairs Antigen Presentation."xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/27529119 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27529119 |
| http://purl.uniprot.org/citations/27529119 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27529119 |
| http://purl.uniprot.org/uniprot/#_P19711-mappedCitation-27529119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27529119 |
| http://purl.uniprot.org/uniprot/P19711 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27529119 |