| http://purl.uniprot.org/citations/27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27533081 | http://www.w3.org/2000/01/rdf-schema#comment | "UTX is a histone demethylase gene located on the X chromosome and is a frequently mutated gene in urothelial bladder cancer (UBC). UTY is a paralog of UTX located on the Y chromosome. We performed target capture sequencing on 128 genes in 40 non-metastatic UBC patients. UTX was the most frequently mutated gene (30%, 12/40). Of the genetic alterations identified, 75% were truncating mutations. UTY copy number loss was detected in 8 male patients (22.8%, 8/35). Of the 9 male patients with UTX mutations, 6 also had copy number loss (66.7%). To evaluate the functional roles of UTX and UTY in tumor progression, we designed UTX and UTY single knockout and UTX-UTY double knockout experiments using a CRISPR/Cas9 lentiviral system, and compared the proliferative capacities of two UBC cell lines in vitro. Single UTX or UTY knockout increased cell proliferation as compared to UTX-UTY wild-type cells. UTX-UTY double knockout cells exhibited greater proliferation than single knockout cells. These findings suggest both UTX and UTY function as dose-dependent suppressors of UBC development. While UTX escapes X chromosome inactivation in females, UTY may function as a male homologue of UTX, which could compensate for dosage imbalances."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.11207"xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Lee D.H."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Ahn J."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Kim H.Y."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Ahn Y.H."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Yoon H."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/author | "Bang D."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/pages | "63252-63260"xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/title | "Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer."xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27533081 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27533081 |
| http://purl.uniprot.org/citations/27533081 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27533081 |
| http://purl.uniprot.org/uniprot/#_A0A087X0Y2-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |
| http://purl.uniprot.org/uniprot/#_F4MH27-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |
| http://purl.uniprot.org/uniprot/#_F4MH28-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |
| http://purl.uniprot.org/uniprot/#_F4MH29-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |
| http://purl.uniprot.org/uniprot/#_F4MH30-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |
| http://purl.uniprot.org/uniprot/#_F4MH31-mappedCitation-27533081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27533081 |