| http://purl.uniprot.org/citations/27535340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27535340 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely understood, and further insight could enable therapeutic efforts to reverse fibrosis. Here, we show that integrin beta-1, capable of binding integrin alpha-11, regulates the pro-fibrotic phenotype of myofibroblasts. Integrin beta-1 expression is upregulated in pro-fibrotic myofibroblasts in vivo and is required in vitro for production of fibrotic ECM components, myofibroblast proliferation, migration and contraction. Serine/threonine-protein kinase proteins, also known as P21-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1) are core mediators of pro-fibrotic integrin beta-1 signalling, with YAP-1 capable of perpetuating integrin beta-1 expression. Pharmacological inhibition of either pathway in vivo attenuates liver fibrosis. PAK protein inhibition, in particular, markedly inactivates the pro-fibrotic myofibroblast phenotype, limits scarring from different hepatic insults and represents a new tractable therapeutic target for treating liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12502"xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Martin K."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Hanley N.A."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Friedman S.L."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Harvey E."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Farrow S."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Henderson N.C."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Zeef L."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Streuli C."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Pritchett J."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Piper Hanley K."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Athwal V.S."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Llewellyn J."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Dobie R."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/author | "Mullan A.F."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/pages | "12502"xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/title | "PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27535340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27535340 |
| http://purl.uniprot.org/citations/27535340 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27535340 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQJ3-mappedCitation-27535340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27535340 |