| http://purl.uniprot.org/citations/27535433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27535433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27535433 | http://www.w3.org/2000/01/rdf-schema#comment | "Biosynthetic traffic from the Golgi drives plasma membrane growth. For Drosophila embryo cleavage, this growth is rapid but regulated for cycles of furrow ingression and regression. The highly conserved small G protein Arf1 organizes Golgi trafficking. Arf1 is activated by guanine nucleotide exchange factors, but essential roles for Arf1 GTPase-activating proteins (GAPs) are less clear. We report that the conserved Arf GAP Asap is required for cleavage furrow ingression in the early embryo. Because Asap can affect multiple subcellular processes, we used genetic approaches to dissect its primary effect. Our data argue against cytoskeletal or endocytic involvement and reveal a common role for Asap and Arf1 in Golgi organization. Although Asap lacked Golgi enrichment, it was necessary and sufficient for Arf1 accumulation at the Golgi, and a conserved Arf1-Asap binding site was required for Golgi organization and output. Of note, Asap relocalized to the nuclear region at metaphase, a shift that coincided with subtle Golgi reorganization preceding cleavage furrow regression. We conclude that Asap is essential for Arf1 to function at the Golgi for cleavage furrow biosynthesis. Asap may recycle Arf1 to the Golgi from post-Golgi membranes, providing optimal Golgi output for specific stages of the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e16-05-0272"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e16-05-0272"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Shao W."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Shao W."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Harris T.J."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Harris T.J."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Rodrigues F.F."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/author | "Rodrigues F.F."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/pages | "3143-3155"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/pages | "3143-3155"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/title | "The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/title | "The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/27535433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27535433 |
| http://purl.uniprot.org/citations/27535433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27535433 |
| http://purl.uniprot.org/citations/27535433 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27535433 |
| http://purl.uniprot.org/citations/27535433 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27535433 |