http://purl.uniprot.org/citations/27539087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27539087 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundRegenerating gene (REG) family is composed of antiapoptotic factors and growth factors that affect epithelial cells within the digestive system. Regenerating gene-I has been studied in different cancers. However, it has never been studied in head and neck cancer. We investigated the expression of REG-I in head and neck SCC and its relevance to patient survival rates.MethodsUntreated biopsy specimens of 60 patients with stage IV head and neck SCC were collected, and the expression of REG-I was evaluated using immunohistochemistry. The association between REG-I expression and clinico-pathological features or survival status of the patients was assessed by Chi-square test, Fisher's exact test and Kaplan-Meier method. Cox proportional hazard model was used to identify the independent prognostic factors.ResultsIncidence of lymphatic permeation, vascular invasion and pathological lymph nodes was significantly higher in REG-I negative group (p = 0.008, 0.030 and 0.015, respectively). Overall and cancer-free survival rates were significantly higher in REG-I positive group (p = 0.000434 and 1.0847E-8, respectively). Univariate analysis showed that REG-I was an independent prognostic factor for predicting long-term overall survival (p = 0.002), and multivariate analysis showed that REG-I and lymphatic permeation were independent prognostic factors for predicting long-term disease-free survival (p = 0.001 and 0.022, respectively).ConclusionOur results showed for the first time that, REG-I is expressed in head and neck SCC. REG-I expression is associated with a longer survival status. We conclude that, REG-I might be a prognostic marker in head and neck SSC and should be further investigated."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13000-016-0526-y"xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Ishikawa K."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Suzuki S."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Omori Y."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Kawasaki Y."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Motoyama S."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/author | "Aboshanif M."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/name | "Diagn Pathol"xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/pages | "79"xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/title | "Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma."xsd:string |
http://purl.uniprot.org/citations/27539087 | http://purl.uniprot.org/core/volume | "11"xsd:string |
http://purl.uniprot.org/citations/27539087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27539087 |
http://purl.uniprot.org/citations/27539087 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27539087 |
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