| http://purl.uniprot.org/citations/27539661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27539661 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that an αvβ5 integrin/FAK-mediated pathway regulated the phagocytic properties of human trabecular meshwork (HTM) cells. Here we demonstrate that this process is mediated by Rac-1 and a previously unreported signaling pathway that utilizes the Tiam1 as well as a novel ILK/RhoG/ELMO2 signaling pathway. Phagocytosis in both a TM-1 cell line and normal HTM cells was mediated by Rac1 and could be significantly decreased by >75% using the Rac1 inhibitor EHop-016. Knockdown of Rac1 in TM-1 cells also inhibited phagocytosis by 40% whereas overexpression of a constitutively active Rac1 or stimulation with PDGF increased phagocytosis by 83% and 32% respectively. Tiam1 was involved in regulating phagocytosis. Knockdown of Tiam1 inhibited phagocytosis by 72% while overexpression of Tiam1 C1199 increased phagocytosis by 75%. Other upstream effectors of Rac1 found to be involved included ELMO2, RhoG, and ILK. Knockdowns of ELMO2, ILK, and RhoG caused a reduction in phagocytosis by 51%, 55% and 46% respectively. In contrast, knockdown of Vav2 and Dock1 or overexpression of Vav2 Y159/172F did not cause a significant change in phagocytosis. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in TM cells."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2016.08.009"xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Phillips J."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Gonzalez J.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Tong T."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Peters D.M."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Dimeo K."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/author | "Peotter J.L."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/pages | "301-311"xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/title | "Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells."xsd:string |
| http://purl.uniprot.org/citations/27539661 | http://purl.uniprot.org/core/volume | "347"xsd:string |
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