| http://purl.uniprot.org/citations/27546573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27546573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27546573 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic basis of sleep regulation remains poorly understood. In C. elegans, cellular stress induces sleep through epidermal growth factor (EGF)-dependent activation of the EGF receptor in the ALA neuron. The downstream mechanism by which this neuron promotes sleep is unknown. Single-cell RNA sequencing of ALA reveals that the most highly expressed, ALA-enriched genes encode neuropeptides. Here we have systematically investigated the four most highly enriched neuropeptides: flp-7, nlp-8, flp-24, and flp-13. When individually removed by null mutation, these peptides had little or no effect on stress-induced sleep. However, stress-induced sleep was abolished in nlp-8; flp-24; flp-13 triple-mutant animals, indicating that these neuropeptides work collectively in controlling stress-induced sleep. We tested the effect of overexpression of these neuropeptide genes on five behaviors modulated during sleep-pharyngeal pumping, defecation, locomotion, head movement, and avoidance response to an aversive stimulus-and we found that, if individually overexpressed, each of three neuropeptides (nlp-8, flp-24, or flp-13) induced a different suite of sleep-associated behaviors. These overexpression results raise the possibility that individual components of sleep might be specified by individual neuropeptides or combinations of neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2016.07.048"xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2016.07.048"xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Schwarz E.M."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Schwarz E.M."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Chow E.S."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Chow E.S."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Nath R.D."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/author | "Nath R.D."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/pages | "2446-2455"xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/pages | "2446-2455"xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/title | "C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/title | "C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/27546573 | http://purl.uniprot.org/core/volume | "26"xsd:string |