| http://purl.uniprot.org/citations/27546891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27546891 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMP) exert its biological functions by interacting with membrane bound receptors. However, functions of BMPs are also regulated in the extracellular space by secreted antagonistic regulators, such as chordin and noggin. Although the deep involvement of BMP signaling in the development and functions of the trigeminal nuclei has been postulated, little information is available for its expression in the trigeminal nuclei. We, thus, investigated chordin and noggin expression in the adult rat trigeminal nuclei using immunohistochemistry. Chordin and noggin were intensely expressed throughout the trigeminal nuclei. In addition, interesting differences are observed between chordin expression and noggin expression. For example, chordin prefers dendritic expression than noggin, suggesting that chordin is involved in the regulation of dendritic morphology and synaptic homeostasis. Furthermore, chordin and noggin were differentially expressed in the neuropil of the trigeminal nuclei. Since BMP signaling is known to play a pivotal role to make precise neural network, theses differences might be important to keep precise interneuronal connections by regulating local BMP signaling intensity in each region. Interestingly, we also detected chordin and noggin expression in axons of the trigeminal nerves. These data indicate that chordin and noggin play pivotal roles also in the adult trigeminal system."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jchemneu.2016.08.003"xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/author | "Mikawa S."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/author | "Katou F."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/author | "Masumoto K."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/name | "J Chem Neuroanat"xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/pages | "36-41"xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/title | "Chordin and noggin expression in the adult rat trigeminal nuclei."xsd:string |
| http://purl.uniprot.org/citations/27546891 | http://purl.uniprot.org/core/volume | "78"xsd:string |
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