| http://purl.uniprot.org/citations/27547819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27547819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27547819 | http://www.w3.org/2000/01/rdf-schema#comment | "Mycolic acids are indispensible lipids of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), and contribute to the distinctive architecture and impermeability of the mycobacterial cell envelope. FadD32 plays a pivotal role in mycolic acid biosynthesis by functionally linking fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic pathways. FadD32, a fatty acyl-AMP ligase (FAAL), represents one of the best genetically and chemically validated new TB drug targets. We have determined the three-dimensional crystal structure of Mtb FadD32 in complex with a ligand specifically designed to stabilize the catalytically active adenylate-conformation, which provides a foundation for structure-based drug design efforts against this essential protein. The structure also captures the unique interactions of a FAAL-specific insertion sequence and provides insight into the specificity and mechanism of fatty acid transfer."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.org/dc/terms/identifier | "doi:10.1021/acsinfecdis.6b00082"xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.org/dc/terms/identifier | "doi:10.1021/acsinfecdis.6b00082"xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Anderson W.F."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Anderson W.F."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Kuhn M.L."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Kuhn M.L."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Shi C."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Shi C."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Minasov G."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Minasov G."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Shuvalova L."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Shuvalova L."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Aldrich C.C."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Aldrich C.C."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Wilson D.J."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Wilson D.J."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Alexander E."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Alexander E."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Flores K.J."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Flores K.J."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Page H.J."xsd:string |
| http://purl.uniprot.org/citations/27547819 | http://purl.uniprot.org/core/author | "Page H.J."xsd:string |