| http://purl.uniprot.org/citations/27550812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27550812 | http://www.w3.org/2000/01/rdf-schema#comment | "Forkhead box O (FOXO; DAF-16 in nematode) transcription factors activate a program of genes that control stress resistance, metabolism, and lifespan. Given the adverse impact of the stochastic DNA damage on organismal development and ageing, we examined the role of FOXO/DAF-16 in UV-induced DNA-damage response. Knockdown of FOXO1, but not FOXO3a, increases sensitivity to UV irradiation when exposed during S phase, suggesting a contribution of FOXO1 to translesion DNA synthesis (TLS), a replicative bypass of UV-induced DNA lesions. Actually, FOXO1 depletion results in a sustained activation of the ATR-Chk1 signaling and a reduction of PCNA monoubiquitination following UV irradiation. FOXO1 does not alter the expression of TLS-related genes but binds to the protein replication protein A (RPA1) that coats single-stranded DNA and acts as a scaffold for TLS. In Caenorhabditis elegans, daf-16 null mutants show UV-induced retardation in larval development and are rescued by overexpressing DAF-16 mutant lacking transactivation domain, but not substitution mutant unable to interact with RPA-1. Thus, our findings demonstrate that FOXO1/DAF-16 is a functional component in TLS independently of its transactivation activity."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00265-16"xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Daitoku H."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Fukamizu A."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Kaneko Y."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Araoi S."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Yoshimochi K."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/author | "Sakamaki J.I."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/pages | "2755-2766"xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/title | "Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis."xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/27550812 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27550812 |
| http://purl.uniprot.org/citations/27550812 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27550812 |
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| http://purl.uniprot.org/uniprot/#_Q19537-mappedCitation-27550812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27550812 |
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