| http://purl.uniprot.org/citations/27554167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27554167 | http://www.w3.org/2000/01/rdf-schema#comment | "The proper regulation of the localization, translation, and stability of maternally deposited transcripts is essential for embryonic development in many organisms. These different forms of regulation are mediated by the various protein subunits of the ribonucleoprotein (RNP) complexes that assemble on maternal mRNAs. However, while many of the subunits that regulate the localization and translation of maternal transcripts have been identified, relatively little is known about how maternal mRNAs are stockpiled and stored in a stable form to support early development. One of the best characterized regulators of maternal transcripts is Cup - a broadly conserved component of the maternal RNP complex that in Drosophila acts as a translational repressor of the localized message oskar. In this study, we have found that loss of cup disrupts the localization of both the oskar mRNA and its associated proteins to the posterior pole of the developing oocyte. This defect is not due to a failure to specify the oocyte or to disruption of RNP transport. Rather, the localization defects are due to a drop in oskar mRNA levels in cup mutant egg chambers. Thus, in addition to its role in regulating oskar mRNA translation, Cup also plays a critical role in controlling the stability of the oskar transcript. This suggests that Cup is ideally positioned to coordinate the translational control function of the maternal RNP complex with its role in storing maternal transcripts in a stable form."xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2016.06.040"xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/author | "Wilhelm J.E."xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/author | "Monfort E."xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/author | "Broyer R.M."xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/pages | "77-85"xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/title | "Cup regulates oskar mRNA stability during oogenesis."xsd:string |
| http://purl.uniprot.org/citations/27554167 | http://purl.uniprot.org/core/volume | "421"xsd:string |
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