| http://purl.uniprot.org/citations/27554857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27554857 | http://www.w3.org/2000/01/rdf-schema#comment | "Fascin is an F-actin-bundling protein shown to stabilize filopodia and regulate adhesion dynamics in migrating cells, and its expression is correlated with poor prognosis and increased metastatic potential in a number of cancers. Here, we identified the nuclear envelope protein nesprin-2 as a binding partner for fascin in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin within filopodia at the cell periphery. Moreover, disrupting the interaction between fascin and nesprin-2 C-terminal domain leads to specific defects in F-actin coupling to the nuclear envelope, nuclear movement, and the ability of cells to deform their nucleus to invade through confined spaces. Together, our results uncover a role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2016.07.021"xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Chang W."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Antoku S."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Parsons M."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Ortiz-Zapater E."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Gundersen G.G."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Jayo A."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Charras G."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Pfisterer K."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Groen C."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Malboubi M."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/author | "Tootle T."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/pages | "371-383"xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/title | "Fascin Regulates Nuclear Movement and Deformation in Migrating Cells."xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/27554857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27554857 |
| http://purl.uniprot.org/citations/27554857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27554857 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEE4-mappedCitation-27554857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27554857 |
| http://purl.uniprot.org/uniprot/#_A0A384MEG1-mappedCitation-27554857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27554857 |
| http://purl.uniprot.org/uniprot/#_B3KTA3-mappedCitation-27554857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27554857 |
| http://purl.uniprot.org/uniprot/#_A4V441-mappedCitation-27554857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27554857 |