| http://purl.uniprot.org/citations/27556504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27556504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27556504 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell quiescence is controlled by regulated genome-encoded programs that actively express genes which are often down-regulated or inactivated in transformed cells. Among them is FoxO1, a transcription factor that imposes quiescence in several cell types, including T lymphocytes. In these cells, the FAM65B encoding gene is a major target of FOXO1. Here, we show that forced expression of FAM65B in transformed cells blocks their mitosis because of a defect of the mitotic spindle, leading to G2 cell cycle arrest and apoptosis. Upon cell proliferation arrest, FAM65B is engaged in a complex containing two proteins well known to be involved in cell proliferation i.e. the HDAC6 deacetylase and the 14.3.3 scaffolding protein. In primary T cells, FAM65B is down-regulated upon T cell receptor engagement, and maintaining its expression blocks their proliferation, establishing that the decrease of FAM65B expression is required for proliferation. Conversely, inhibiting FAM65B expression in naive T lymphocytes decreases their activation threshold. These results identify FAM65B as a potential new target for controlling proliferation of both transformed and normal cells."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.11438"xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.11438"xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Mangeney M."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Mangeney M."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Meunier S."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Meunier S."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Bismuth G."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Bismuth G."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Froehlich J."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Froehlich J."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Versapuech M."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Versapuech M."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Delon J."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Delon J."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Largeteau Q."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Largeteau Q."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Megrelis L."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Megrelis L."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Tanchot C."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/author | "Tanchot C."xsd:string |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27556504 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |