| http://purl.uniprot.org/citations/27561390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27561390 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis. Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress. Ubiquitin chain-restriction analysis provides evidence that CYLD removes K48 ubiquitin chains from p53 indirectly by cleaving K63 linkages, suggesting that p53 is decorated with complex K48/K63 chains. Moreover, CYLD deficiency also diminishes CEP-1/p53-dependent DNA damage-induced germ cell apoptosis in the nematode Caenorhabditis elegans. Collectively, our results identify CYLD as a deubiquitinase facilitating DNA damage-induced p53 activation and suggest that regulation of p53 responses to genotoxic stress contributes to the tumour suppressor function of CYLD."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12508"xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Schell M."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Schumacher B."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Komander D."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Buttner R."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Ermolaeva M.A."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Adam A."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Pasparakis M."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Thomas R.K."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Fernandez-Majada V."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Welz P.S."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/author | "Dietlein F."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/pages | "12508"xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/title | "The tumour suppressor CYLD regulates the p53 DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27561390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27561390 |
| http://purl.uniprot.org/citations/27561390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27561390 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-27561390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561390 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-27561390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561390 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-27561390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561390 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-27561390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561390 |