| http://purl.uniprot.org/citations/27561680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27561680 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively translocated to the mitochondria, where it is bound to mtHtt in various HD models. Mitochondria-accumulated VCP elicits excessive mitophagy, causing neuronal cell death. Blocking mtHtt/VCP mitochondrial interaction with a peptide, HV-3, abolishes VCP translocation to the mitochondria, corrects excessive mitophagy and reduces cell death in HD mouse- and patient-derived cells and HD transgenic mouse brains. Treatment with HV-3 reduces behavioural and neuropathological phenotypes of HD in both fragment- and full-length mtHtt transgenic mice. Our findings demonstrate a causal role of mtHtt-induced VCP mitochondrial accumulation in HD pathogenesis and suggest that the peptide HV-3 might be a useful tool for developing new therapeutics to treat HD."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12646"xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Fujioka H."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Hu D."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Wang Y.J."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Mochly-Rosen D."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Vyas R."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Chakrapani S."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/author | "Joshi A.U."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/pages | "12646"xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/title | "VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease."xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27561680 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27561680 |
| http://purl.uniprot.org/citations/27561680 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27561680 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGY4-mappedCitation-27561680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561680 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV32-mappedCitation-27561680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561680 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV40-mappedCitation-27561680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561680 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVK5-mappedCitation-27561680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27561680 |