| http://purl.uniprot.org/citations/27562263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27562263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27562263 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppression of major histocompatibility complex (MHC) class II antigen presentation is believed to be among the major mechanisms used by Mycobacterium tuberculosis to escape protective host immune responses. Through a genome-wide screen for the genetic loci of M. tuberculosis that inhibit MHC class II-restricted antigen presentation by mycobacteria-infected dendritic cells, we identified the PE_PGRS47 protein as one of the responsible factors. Targeted disruption of the PE_PGRS47 (Rv2741) gene led to attenuated growth of M. tuberculosis in vitro and in vivo, and a PE_PGRS47 mutant showed enhanced MHC class II-restricted antigen presentation during in vivo infection of mice. Analysis of the effects of deletion or over-expression of PE_PGRS47 implicated this protein in the inhibition of autophagy in infected host phagocytes. Our findings identify PE_PGRS47 as a functionally relevant, non-redundant bacterial factor in the modulation of innate and adaptive immunity by M. tuberculosis, suggesting strategies for improving antigen presentation and the generation of protective immunity during vaccination or infection."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmicrobiol.2016.133"xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmicrobiol.2016.133"xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Jacobs W.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Jacobs W.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Chan J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Chan J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Baena A."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Baena A."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Porcelli S.A."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Porcelli S.A."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Larsen M.H."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Larsen M.H."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Saini N.K."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Saini N.K."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Carreno L.J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Carreno L.J."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Kennedy S.C."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Kennedy S.C."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Kunnath-Velayudhan S."xsd:string |
| http://purl.uniprot.org/citations/27562263 | http://purl.uniprot.org/core/author | "Kunnath-Velayudhan S."xsd:string |