| http://purl.uniprot.org/citations/27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27563808 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-23p19 plays important roles in intestinal antimicrobial immunity, while its over-expression can lead to intestinal inflammation. However, the bacterial compounds and the type of pattern recognition receptor involved in the inducible expression of IL-23p19 in Paneth cells remain unclear. Here we show that the mRNA expression of IL-23p19 was increased in Paneth cell (PC)-like cells stimulated by Toll-like receptor 2 (TLR2) ligands, peptidoglycan (PGN) and Pam3CSK4, and was further increased in the presence of nucleotide-binding oligomerization domain 2 (NOD2)-ligand muramyl dipeptide (MDP). However, its mRNA expression was decreased in NOD2-knockdown PC-like cells. Additionally, the c-Rel activation was increased in Pam3CSK4- or PGN-stimulated PC-like cells, but the PGN-induced c-Rel activation was decreased in NOD2-knockdown PC-like cells and had no significant difference compared with Pam3CSK4-induced c-Rel activation. Our results suggest that NOD2 up-regulates TLR2-mediated IL-23p19 expression via increasing c-Rel activation in PC-like cells. This finding might provide us with a novel therapeutic target for inflammatory bowel disease to inhibit IL-23p19 over-expression via the NOD2-c-Rel pathway."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.11467"xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Deng F."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Tan G."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Liao K."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Liang E."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/author | "Zhi F."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/pages | "63651-63660"xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/title | "NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-kappaB subunit c-Rel in Paneth cell-like cells."xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27563808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27563808 |
| http://purl.uniprot.org/citations/27563808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27563808 |
| http://purl.uniprot.org/uniprot/#_D9N2T7-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S4-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L7-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A3FA72-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A0A8D5XLR4-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPL7-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |
| http://purl.uniprot.org/uniprot/#_A0A286YF65-mappedCitation-27563808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27563808 |