| http://purl.uniprot.org/citations/27565023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27565023 | http://www.w3.org/2000/01/rdf-schema#comment | "The fruit fly Drosophila melanogaster has two types of external visual organs, a pair of compound eyes and a group of three ocelli. At the time of neurogenesis, the proneural transcription factor Atonal mediates the transition from progenitor cells to differentiating photoreceptor neurons in both organs. In the developing compound eye, atonal (ato) expression is directly induced by transcriptional regulators that confer retinal identity, the Retinal Determination (RD) factors. Little is known, however, about control of ato transcription in the ocelli. Here we show that a 2kb genomic DNA fragment contains distinct and common regulatory elements necessary for ato induction in compound eyes and ocelli. The three binding sites that mediate direct regulation by the RD factors Sine oculis and Eyeless in the compound eye are also required in the ocelli. However, in the latter, these sites mediate control by Sine oculis and the other Pax6 factor of Drosophila, Twin of eyeless, which can bind the Pax6 sites in vitro. Moreover, the three sites are differentially utilized in the ocelli: all three are similarly essential for atonal induction in the posterior ocelli, but show considerable redundancy in the anterior ocellus. Strikingly, this difference parallels the distinct control of ato transcription in the posterior and anterior progenitors of the developing compound eyes. From a comparative perspective, our findings suggest that the ocelli of arthropods may have originated through spatial partitioning from the dorsal edge of an ancestral compound eye."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2016.08.025"xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/author | "Friedrich M."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/author | "Pignoni F."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/author | "DeSantis D.F."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/pages | "10-16"xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/title | "Shared and distinct mechanisms of atonal regulation in Drosophila ocelli and compound eyes."xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://purl.uniprot.org/core/volume | "418"xsd:string |
| http://purl.uniprot.org/citations/27565023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27565023 |
| http://purl.uniprot.org/citations/27565023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27565023 |
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| http://purl.uniprot.org/uniprot/#_P48987-mappedCitation-27565023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27565023 |
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| http://purl.uniprot.org/uniprot/#_C0MKM8-mappedCitation-27565023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27565023 |
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