| http://purl.uniprot.org/citations/27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27566940 | http://www.w3.org/2000/01/rdf-schema#comment | "B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells that occurs in the anatomically distant dark zone. Here, we show that the transcription factor AP4 was required for sustained GC B cell proliferation and subsequent establishment of a diverse and protective antibody repertoire. AP4 was induced by c-MYC during the T-B interactions, was maintained by T-cell-derived interleukin-21 (IL-21), and promoted repeated rounds of divisions of selected GC B cells. B-cell-specific deletion of AP4 resulted in reduced GC sizes and reduced somatic hypermutation coupled with a failure to control chronic viral infection. These results indicate that AP4 integrates T-cell-mediated selection and sustained expansion of GC B cells for humoral immunity."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.07.023"xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Bhattacharya D."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Egawa T."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Chou C."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Holmgren M."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Tonc E."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/author | "Verbaro D.J."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/pages | "570-582"xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/title | "The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses."xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/27566940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27566940 |
| http://purl.uniprot.org/citations/27566940 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27566940 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR2-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP02-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P4-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_E0CXQ9-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-27566940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27566940 |