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http://purl.uniprot.org/citations/27567475http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27567475http://www.w3.org/2000/01/rdf-schema#comment"L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.org/dc/terms/identifier"doi:10.1016/j.jphs.2016.07.006"xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Hayashi K."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Maeda S."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Fujita T."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Anzai N."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Endou H."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Ouchi M."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Jutabha P."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Chida M."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/author"Supak Y."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/name"J Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/pages"201-204"xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/title"LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells."xsd:string
http://purl.uniprot.org/citations/27567475http://purl.uniprot.org/core/volume"132"xsd:string
http://purl.uniprot.org/citations/27567475http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27567475
http://purl.uniprot.org/citations/27567475http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27567475
http://purl.uniprot.org/uniprot/#_A0A0C4DGL4-mappedCitation-27567475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27567475
http://purl.uniprot.org/uniprot/#_Q01650-mappedCitation-27567475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27567475
http://purl.uniprot.org/uniprot/#_Q2MCL6-mappedCitation-27567475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27567475
http://purl.uniprot.org/uniprot/#_Q96QB2-mappedCitation-27567475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27567475
http://purl.uniprot.org/uniprot/Q01650http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27567475
http://purl.uniprot.org/uniprot/A0A0C4DGL4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27567475